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Some coumarins were sythesized for the screening of their cytotoxic activities against L1210 cell. Of the coumarins sythesized, 6,7-dihydroxycoumarin (esculetin) and 7,8-dihydroxycoumarin (daphnetin) as coumarins with dioxygenated A-ring, and 6-acetoxy-5,7-dimethoxycoumarin and 5,7-dimethoxy-6-hydroxycoumarin as trioxygenated ones, show considerable cytotoxic activities, ED 50 being 4.3, 8.8, 17.2 and 5.5mcg/ml in the same order as the substances. The extent of oxygenation of the A-ring and the positions of the oxygen functions eventually play an important role for the cytotoxic activity.
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